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Malignancies

Development of cholangiocarcinoma (CCA) in PSC (i.e. PSC/CCA) represents a major challenging issue, with a number of problems to tackle from both clinical and experimental perspectives. Among them, uncertainty in early diagnosis, limited human sample availability and lack of experimental models of PSC/CCA (i.e. in vitro and in vivo) have been identified as critical needs worth of investigation by specific proposals discussed in New Haven.

Current projects (June 2018)

  1. To define “CCA subtype”-specific radiology (MRI) parameters through radiologic/histo-morphology correlates and their clinical application for the early diagnosis of CCA/PSC (proposed by V. Cardinale, D. Alvaro, Rome).
  2. To develop a registry of PSC/CCA with sample collection (tissue, bile, blood, urine) and clinical data recording within the European Network for the Study of CCA (ENS-CCA), coordinated by J. Banales (San Sebastian).
  3. To define an animal model of PSC/CCA as tool to unravel pathogenetic mechanisms and eventually, develop novel treatment strategies (proposed by L. Fabris, V. Cardinale, J. Mertens, Padua, Rome, Zurich).

Proposal#1 and Proposal#3 will be developed in collaboration with WG on ‘Imaging Studies’, and with WG on ‘Animal & Cellular Models & Pathophysiology’, respectively.